Antitrypanosomal effect of methanolic extract of Zingiber officinale (ginger) on Trypanosoma brucei brucei-infected Wistar mice - P. I. Kobo, P. J. Erin, M. M. Suleiman, H. Aliyu, M. Tauheed, S. Muftau and M. Mamman
Veterinary World, 7(10): 770-775
doi: 10.14202/vetworld.2014.770-775
P. I. Kobo: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;
patriciakobo@yahoo.com
P. J. Erin: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;pius4u2c@yahoo.com
M. M. Suleiman: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;mohsulai@yahoo.com
H. Aliyu: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;haliyu63@gmail.com
M. Tauheed: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;mtauheed40@yahoo.com
S. Muftau: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;shittumuftau@yahoo.com
M. Mamman: Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria;mammanm@hotmail.com
Received: 15-05-2014, Revised: 18-08-2014, Accepted: 24-08-2014, Published online: 05-10-2014
Corresponding author: Patricia Ishaku Kobo, e-mail: patriciakobo@yahoo.com
Aim: The study was carried out to determine the in vivo antitrypanosomal effect of methanolic extract of Zingiber officinale (ginger) inTrypanosoma brucei brucei-infected mice.
Materials and Methods: Twenty-five mice were randomly allocated into five groups of five animals each. Group I and II were given Tween 80 (1 ml/kg) and diminazene aceturate (3.5 mg/kg) to serve as untreated and treated controls, respectively. Groups III-V received the extract at 200, 400 and 800 mg/kg body weight, respectively. All treatments were given for 6 consecutive days and through the oral route. The mean body weight, mean survival period and daily level of parasitaemia were evaluated.
Results: Acute toxicity showed the extract to be relatively safe. There was an insignificant increase in body weight and survival rate of mice treated with the extract. The level of parasitaemia in the extract treated groups was decreased.
Conclusion: This study shows the in vivo potential of methanolic extract of Z. officinale in the treatment of trypanosomiasis.
Keywords: parasitaemia, survival rate, trypanosomiasis, Zingiber officinale.
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